| Full text | |
| Author(s): |
Carrepeiro, Mariana Magalhaes
[1]
;
Rogero, Marcelo Macedo
[2]
;
Bertolami, Marcelo Chiara
[3]
;
Botelho, Patricia Borges
[1]
;
Castro, Natalia
[1]
;
Castro, Inar Alves
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-140550890 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Publ Hlth, Dept Nutr, BR-05508900 Sao Paulo - Brazil
[3] Dante Pazzanese Inst Cardiol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ATHEROSCLEROSIS; v. 217, n. 1, p. 171-178, JUL 2011. |
| Web of Science Citations: | 17 |
| Abstract | |
Introduction: Although the combination of statins with n-3 fatty acids seems to be beneficial under the lipid profile aspect, there is little information about the interaction of these two compounds on oxidative stress. Objective: Evaluate the interaction between statins and n-3 fatty acids on oxidative stress in women, using a 2(2) factorial design. Methods: Forty-three women participated in this crossover design. They were separated into two groups in which 20 were under statin treatment for more than 6 months, and 23 were normolipidemic. Within each group, half of the patients received capsules containing 2.4 g/day of a mixture of EPA and DHA for 6 weeks, while the other half received a mixture of soya and corn oil. After a period of 90 days of washout, the groups were switched, and received the supplementation for 6 weeks more. Results: Statins reduced serum LDL and increased SOD expression. n-3 fatty acids increased the plasma malondialdehyde and SOD activity but reduced catalase expression (p < 0.05). The interaction involving statins and n-3 fatty acids was nearly significant to the serum triacylglycerol reduction (p = 0.054). Conclusion: Combining statins and n-3 fatty acids is an excellent strategy to reduce plasma cholesterol and triacylglycerol concentration in women. However, n-3 fatty acids increased the oxidative stress and the pleiotropic effect of statins seemed to be not enough to counterbalance this result. Our data also suggested that the mechanism by which n-3 fatty acids interfere in oxidative stress can be associated with antioxidant enzymes expression and activity. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 08/09296-1 - Use of factorial designs to develop a model to evaluate oil and emulsion oxidation. |
| Grantee: | Inar Castro Erger |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 07/05770-8 - Effect of omega 3 polyunsaturated fatty acids combined with statins in oxidative stress biomarkers of dislipidemic individuals. |
| Grantee: | Mariana de Magalhães Carrapeiro |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 07/07954-9 - Efeito do uso combinado de acidos graxos polinsaturados omega 3 e estatinas nos biomarcadores do stress oxidativo em individuos com dislipidemia. |
| Grantee: | Inar Castro Erger |
| Support Opportunities: | Regular Research Grants |