Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?

Author(s)

Malveira, Alice da Silva ; Alves, Vanessa ; de Matuoka e Chiocchetti, Gabriela ; Gambero, Alessandra ; de Avila, Amanda Rejane Alves ; Furtado, Guilherme de Figueiredo ; Macedo, Juliana Alves ; Luccas, Valdecir ; Macedo, Gabriela Alves

• Document type: Journal article
• Source: JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION; v. N/A, p. 9-pg., 2025-01-03.

Abstract

A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.Objective: We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.Methods: SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.Results: SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.Conclusions: Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption. (AU)

• FAPESP's process: 20/07015-7 - PBIS - Integrated Biotechnological Platform of Healthy Ingredients
• Grantee: Maria Teresa Bertoldo Pacheco
• Support Opportunities: Research Grants - Problem-Oriented Research Centers in São Paulo