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Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?

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Author(s):
Malveira, Alice da Silva ; Alves, Vanessa ; de Matuoka e Chiocchetti, Gabriela ; Gambero, Alessandra ; de Avila, Amanda Rejane Alves ; Furtado, Guilherme de Figueiredo ; Macedo, Juliana Alves ; Luccas, Valdecir ; Macedo, Gabriela Alves
Total Authors: 9
Document type: Journal article
Source: JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION; v. N/A, p. 9-pg., 2025-01-03.
Abstract

A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.Objective: We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.Methods: SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.Results: SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.Conclusions: Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption. (AU)

FAPESP's process: 20/07015-7 - PBIS - Integrated Biotechnological Platform of Healthy Ingredients
Grantee:Maria Teresa Bertoldo Pacheco
Support Opportunities: Research Grants - Problem-Oriented Research Centers in São Paulo