Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review

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Martignago, Cintia Cristina Santi ; Barbosa, Camila de Souza ; Motta, Homero Garcia ; Soares-Silva, Beatriz ; Peres, Erica Paloma Maso Lopes ; Silva, Lais Caroline ; Bonifacio, Mirian ; Sousa, Karolyne dos Santos Jorge ; Alqualo, Amanda Sardeli ; Parisi, Julia ; Jordan, Olivier ; Renno, Ana Claudia Muniz ; Aguiar, Anna Caroline Campos ; Patrulea, Viorica

• Document type: Journal article
• Source: MARINE DRUGS; v. 23, n. 1, p. 17-pg., 2025-01-01.

Abstract

The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting Pseudomonas aeruginosa, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents. (AU)

• FAPESP's process: 23/13928-3 - DEVELOPING mPEG-PLA MICELLES FOR THE DELIVERY OF THE BIOACTIVE COMPOUND EXTRACTED FROM MARINE SPONGE DYSIDEA ROBUSTA AGAINST MULTIDRUG RESISTANT BACTERIA
• Grantee: Cintia Cristina Santi Martignago
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 19/19708-0 - Identification of new antimalarial compounds: a multidisciplinary strategy aimed to search for potent chemical classes against new molecular targets and different stages of life of Plasmodium spp
• Grantee: Anna Caroline Campos Aguiar
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/02974-9 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system
• Grantee: Cintia Cristina Santi Martignago
• Support Opportunities: Scholarships in Brazil - Post-Doctoral