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Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain

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Author(s):
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Jia, Huiqiong ; Tong, Qingchao ; Wang, Le ; Wu, Yuye ; Li, Xinyang ; Li, Shuangshuang ; Kong, Yingying ; Zhang, Yingying ; Furlan, Pedro Rueda ; Khine, Nwai Oo ; Butaye, Patrick ; Zhang, Jun ; Yang, Qing ; Ruan, Zhi
Total Authors: 14
Document type: Journal article
Source: DRUG RESISTANCE UPDATES; v. 79, p. 4-pg., 2024-12-27.
Abstract

To characterize the genomic features of a community-acquired Acinetobacter baumannii strain, co-carrying tet(X6) and blaOXA-58 genes, but was susceptible to tigecycline and carbapenems. The tet(X6) and blaOXA-58 genes were found on a 149,518 bp non-conjugative plasmid. The blaOXA-58 gene was silent, due to the presence of an intact ISAba3-like element upstream, which rendered the strain susceptible to carbapenems. (AU)

FAPESP's process: 23/16216-4 - Genomic investigation of probiotics/bacteriocins for the treatment of antimicrobial-resistant pathogens
Grantee:João Pedro Rueda Furlan
Support Opportunities: Scholarships in Brazil - Post-Doctoral