Intraoral Lymphomatoid Papulosis Type D Showing Scarce/Absent CD30 Expression in A Pediatric Patient: Case Report and Literature Review

Author(s)

Palacon, Mariana Paravani ; Marques, Marcelo Borges ; Silveira, Debora Fernandes Mendes ; Martins, Karina Helen ; Silveira, Heitor Albergoni ; Pereira-Filho, Valfrido Antonio ; Bufalino, Andreia ; Chahud, Fernando ; Leon, Jorge Esquiche

• Document type: Journal article
• Source: Head and Neck Pathology; v. 19, n. 1, p. 5-pg., 2025-02-05.

Abstract

Purpose Approximately 10% of all lymphomatoid papulosis (LyP) cases affect pediatric patients. Pediatric LyP is clinically similar to adult LyP, frequently with cutaneous involvement, whereas the affectation of mucosal surface is rare. The LyP clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement, with LyP type D representing < 5% of all LyP cases. Methods We have previously reported 2 cases of exclusively intraoral LyP type C and E. To date, about 50 cases of LyP type D have been reported; of them, 8 cases, all but one with exclusive skin involvement, corresponded to pediatric patients. Rare LyP type C cases can lack CD30 expression, creating diagnostic difficulties with lymphoma. Results Here, we report an extremely rare case of intraoral LyP type D with scarce/absent CD30 expression affecting a 12-year-old white Brazilian boy. Conclusions To our best knowledge, this is the first pediatric case of LyP type D with exclusive intraoral involvement. (AU)

• FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas
• Grantee: Jorge Esquiche León
• Support Opportunities: Regular Research Grants