| Full text | |
| Author(s): Show less - |
de Barros, Natan Roberto
;
Chagas, Ana Laura Destro
;
Forster, Samuel
;
Brasil, Giovana Sant'Ana Pegorin
;
Ribeiro, Geraldo Monteiro
;
Olivato, Orestes Pereira
;
Ramalho, Leandra Naira Zambelli
;
Guerra, Nayrim Brizuela
;
Mussagy, Cassamo Ussemane
;
Floriano, Juliana Ferreira
;
Barbosa, Angelica Mercia Pascon
;
Rudge, Marilza Vieira Cunha
;
Silva, Rosangela Goncalves
;
Farhadi, Neda
;
Mohaghegh, Neda
;
Monirizad, Mahsa
;
Peirsman, Arne
;
Gomez, Alejandro
;
de Mendonca, Ricardo Jose
;
dos Santos, Lindomar Soares
;
Marcaccini, Andrea Marcia
;
Tognoli, Silvia
;
Binotto, Cibele Correia S.
;
Domingues, Aline Natalia
;
Jucaud, Vadim
;
Mendes, Adriana Aparecida
;
Oliveira, Amanda Santos
;
Li, Bingbing
;
Herculano, Rondinelli Donizetti
Total Authors: 29
|
| Document type: | Journal article |
| Source: | International Journal of Biological Macromolecules; v. 308, p. 20-pg., 2025-05-01. |
| Abstract | |
Diabetic Foot Ulcers (DFUs) are a common and severe complication of long-term, poorly managed type 2 diabetes. Among the 537 million people worldwide with type 2 diabetes, 19 % to 34 % are expected to develop a DFU in their lifetime. As life expectancy increases, so does the prevalence of DFUs, leading to complex and costly long-term care. This study introduces a novel, flexible dressing composed of natural rubber latex (NRL) infused with collagen (NRL-C), leveraging the natural healing properties of these biomaterials. The efficacy of NRL-C was validated through physicochemical characterization, in vitro and in vivo studies, and a pilot clinical trial. Results demonstrated that the NRL-C dressing promotes angiogenesis in endothelial cells, stimulates fibroblast and keratinocyte proliferation, accelerates wound closure, and exhibits biocompatibility in rodent models. Additionally, a pilot clinical study involving six diabetic patients revealed promising therapeutic outcomes, highlighting the potential of NRL-C as a cost-effective, safe, and sustainable strategy for DFU treatment. (AU) | |
| FAPESP's process: | 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair |
| Grantee: | Rondinelli Donizetti Herculano |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier |
| Grantee: | Rondinelli Donizetti Herculano |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 23/17448-6 - "EMU: Acquisition of 3D bioprinting, laser cutting and fluorescence microscope for implementation of organs-on-a-chip and organoids facility" |
| Grantee: | Rondinelli Donizetti Herculano |
| Support Opportunities: | Research Infrastructure Program - Small Medium Sized |
| FAPESP's process: | 17/02518-8 - Development of polymer blends of latex-alginate and latex-collagen for tissue engineering application |
| Grantee: | Natan Roberto de Barros |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/07342-8 - Development of microfluidic devices/organ on a chip using xurography, poliester-toner and gelatin methacryloyl (GelMA) |
| Grantee: | Rondinelli Donizetti Herculano |
| Support Opportunities: | Scholarships abroad - Research |