Advanced search
Start date
Betweenand


Enhancing hydroxychloroquine detection using carbon paste electrode modified with platinum nanoparticles and MWCNTs

Full text
Author(s):
Feitosa, Maria H. A. ; Santos, Anderson M. ; Wong, Ademar ; Sotomayor, Maria D. P. T. ; Barros, Willyam R. P. ; Lanza, Marcos R. V. ; Moraes, Fernando C.
Total Authors: 7
Document type: Journal article
Source: Journal of Applied Electrochemistry; v. N/A, p. 12-pg., 2025-03-11.
Abstract

In this study, a carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs) and platinum nanoparticles (Pt NPs) was developed for the detection of hydroxychloroquine in environmental and biologic samples. The electrodes defined as MWCNTs/CPE and Pt NPs-MWCNTs/CPE, were subjected to characterization analyses, where their structural and morphological properties were investigated. The electrochemical measurements were carried out using cyclic and square wave voltammetry techniques. Under optimal conditions, the proposed sensor displayed a linear concentration range of 0.099-7.1 mu mol L-1 (n = 3) in 0.10 mol L-1 phosphate buffer solution at pH 6.0, with detection and quantification limits of 28 nmol L-1 and 93 nmol L-1, respectively. The selectivity of the proposed sensor toward hydroxychloroquine detection was verified in the presence of potential interferents, such as uric acid, glucose, urea, ascorbic acid, albumin, metals, and humic acid. For the analysis of its applicability, the sensor was successfully applied for hydroxychloroquine detection in biologic and environmental samples, where the results obtained were comparable to those obtained under spectrophotometry (reference method), thus confirming the feasibility of the method. The findings of this study show that the proposed sensor exhibits exceptional performance and is suitable for use in the detection of pharmaceuticals in different real matrices.Graphical abstract"Schematic representation of the fabrication of a carbon paste electrode modified with carbon nanotubes and platinum nanoparticles, and its application in the determination of hydroxychloroquine in urine, serum, and river water samples using square wave voltammetry." (AU)

FAPESP's process: 22/05454-9 - Development of disposable electrochemical sensors and photoanodes manufactured with nanostructured semiconductor materials for the determination and degradation of endocrine disruptors
Grantee:Fernando Cruz de Moraes
Support Opportunities: Regular Research Grants
FAPESP's process: 19/06650-3 - EMU granted in the 2017/10118-0 process: potentiostat system with impedance module
Grantee:Marcos Roberto de Vasconcelos Lanza
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 23/14335-6 - Development of disposable electrochemical sensors for the determination and online monitoring of emerging contaminants in degradation processes
Grantee:Anderson Martin dos Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/22210-0 - EMU granted in process 2017/10118-0: liquid chromatograph (HPLC)
Grantee:Marcos Roberto de Vasconcelos Lanza
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 22/12895-1 - Advanced processes for the degradation of emerging pollutants: catalytic materials, electroanalytical sensors and scientific dissemination
Grantee:Marcos Roberto de Vasconcelos Lanza
Support Opportunities: Research Projects - Thematic Grants