Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes

Author(s)

Sales, Cristiane Hermes ^[1] ; Campos Pedrosa, Lucia Fatima ^[2] ; Lima, Josivan Gomes ^[3] ; Araujo Moura Lemos, Telma Maria ^[4] ; Colli, Celia ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil

^[2] Univ Fed Rio Grande do Norte, Dept Nutr, BR-59010180 Natal, RN - Brazil

^[3] Univ Fed Rio Grande do Norte, Dept Clin Med, BR-59010180 Natal, RN - Brazil

^[4] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol Anal, BR-59010180 Natal, RN - Brazil

• Document type: Journal article
• Source: Clinical Nutrition; v. 30, n. 3, p. 359-364, JUN 2011.
• Web of Science Citations: 29

Abstract

Background \& aims: This study was undertaken to assess magnesium intake and magnesium status in patients with type 2 diabetes, and to identify the parameters that best predict alterations in fasting glucose and plasma magnesium. Methods: A cross-sectional study was carried out in patients with type 2 diabetes (n = 51; 53.6 +/- 10.5 y) selected within the inclusion factors, at the University Hospital Onofre Lopes. Magnesium intake was assessed by three 24-h recalls. Urine, plasma and erythrocytes magnesium, fasting and 2-h postprandial glucose, HbA1, microalbuminuria, proteinuria, and serum and urine creatinine were measured. Results: Mean magnesium intake (9.37 +/- 1.76 mmol/d), urine magnesium (2.80 +/- 1.51 mmol/d), plasma magnesium (0.71 +/- 0.08 mmol/L) and erythrocyte magnesium (1.92 +/- 0.23 mmol/L) levels were low. Seventy-seven percent of participants presented one or more magnesium status parameters below the cut-off points of 3.00 mmol/L for urine, 0.75 mmol/L for plasma and 1.65 mmol/L for erythrocytes. Subjects presented poor blood glucose control with fasting glucose of 8.1 +/- 3.7 mmol/L, 2-h postprandial glucose of 11.1 +/- 5.1 mmol/L, and HbA1 of 11.4 +/- 3.0%. The parameters that influenced fasting glucose were urine, plasma and dietary magnesium, while plasma magnesium was influenced by creatinine clearance. Conclusions: Magnesium status was influenced by kidney depuration and was altered in patients with type 2 diabetes, and magnesium showed to play an important role in blood glucose control. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)