Green synthesis of antimicrobial nanotechnology using flavonoids: a systematic review

Author(s)

Santana Junior, Claudio Carvalho ; Santos, Anamaria Mendonca ; Oliveira, Ana Maria Santos ; Nascimento Junior, Jose Adao Carvalho ; Picot, Laurent ; Frank, Luiza Abrahao ; Menezes, Paula dos Passos ; Alves, Izabel Almeida ; Serafini, Mairim Russo

• Document type: Journal article
• Source: Journal of Microencapsulation; v. N/A, p. 14-pg., 2025-04-04.

Abstract

Antimicrobial resistance (AMR) is a critical public health concern that arises when microorganisms evolve mechanisms to evade the effects of antibiotics, thereby rendering conventional treatments ineffective. This growing challenge underscores the urgent need for novel therapeutic approaches. Nanotechnology, particularly when combined with environmentally sustainable practices such as green synthesis, reduces the use of toxic substances and minimises waste, offering a promising solution. This review explores the green synthesis of antimicrobial nanoparticles using flavonoids-natural compounds with substantial biological activity-as reducing and stabilising agents. By systematically analysing articles from PubMed, Scopus, Web of Science, and Embase, 10 key studies were identified. The primary nanoparticles examined were metallic, including silver, gold, copper, and metallic, which demonstrated notable efficacy against pathogens such as S. aureus, E. coli, and P. aeruginosa. The results support that green-synthesised nanoparticles represent a viable strategy to combat AMR, offering an effective and eco-friendly alternative for developing antimicrobial agents. (AU)

• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants