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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rat skin wound healing induced by alternagin-C, a disintegrin-like, Cys-rich protein from Bothrops alternatus venom

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Author(s):
Correia Sant'Ana, Estela Maria [1] ; Cacao Paiva Gouvea, Cibele Marli [2] ; Quagliotti Durigan, Joao Luiz [1] ; Cominetti, Marcia Regina [1] ; Pimentel, Edson Rosa [3] ; Selistre-de-Araujo, Heloisa Sobreiro [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Alfenas, Inst Ciencias Nat, Alfenas, MG - Brazil
[3] Univ Fed Sao Carlos, Dept Anat Biol Celular & Fisiol & Biofis, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL WOUND JOURNAL; v. 8, n. 3, p. 245-252, JUN 2011.
Web of Science Citations: 13
Abstract

Alternagin-C (ALT-C) is a disintegrin-like, Cys-rich protein isolated from Bothrops alternatus snake venom, which has been shown to induce in vivo angiogenesis. Therefore, this protein could be interesting as a new approach for tissue regeneration studies. Here the effects of ALT-C on fibroblasts and inflammatory cells, collagen type III and type I and TGF-alpha expression in a rat wounded skin model were studied. Thirty-five male Wistar rats (weight 270 +/- 20 g) were divided into seven groups with five animals in each of the following groups: a control group which wounded animals received treatment with natrozol (R) gel only; ALT-C10, ALT-C60 and ALT-C100 groups of wounded animals that were treated with the same amount of gel containing 10, 60 and 100 ng of ALT-C, respectively. Animals were treated once a day with 20 mu l of gel associated or not with ALT-C for 1, 3, 5 or 7 days. ALT-C treatment increased the fibroblast density, collagen deposition and accelerated the inflammatory process, mostly in the ALT-C60 group. These results indicate that ALT-C improves wound repair process in rat skin. Thus, ALT-C could be a candidate to the development of a novel therapeutic strategy for wounded skin repair. (AU)

FAPESP's process: 08/09408-4 - The effect of electric stimulation in quadriceps femoris muscle atrophy after anterior cruciate ligament injury in rats
Grantee:João Luiz Quagliotti Durigan
Support Opportunities: Scholarships in Brazil - Post-Doctoral