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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential response related to genotoxicity in multiple organs of cirrhotic rats

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Author(s):
Nagaoka, Marcia R. [1] ; Le Sueur-Maluf, Luciana [1] ; Aguiar, Jr., Odair [1] ; Castro, Glaucia M. [1] ; Spadari-Bratfisch, Regina C. [1] ; Ribeiro, Daniel A. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Biociencias, Santos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: HEPATOLOGY INTERNATIONAL; v. 5, n. 2, p. 740-746, JUN 2011.
Web of Science Citations: 5
Abstract

The aim of this study was to use the single cell gel (comet) assay to investigate whether blood, liver, heart, kidney, and brain are particularly sensitive organs for DNA damage in cirrhotic rats to predict genetic instability induced by cirrhosis. A total of 16 male Wistar rats (negative control, n = 8; experimental, n = 8) were submitted to bile duct ligation during 28 days. Cirrhosis was able to induce genetic damage in liver and brain cells, as depicted by the mean tail moment. No genetic damage was induced in blood, heart, or kidney cells (i.e., no significant statistically differences were noticed when compared with negative control). In conclusion, our results suggest that cirrhosis could contribute to DNA damage in liver and brain cells. (AU)

FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support Opportunities: Research Grants - Young Investigators Grants