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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection

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Author(s):
Salomao Junior, Joao B. [1] ; Gardinassi, Luiz G. A. [2] ; Simas, Paulo V. M. [3] ; Bittar, Cintia O. [4] ; Souza, Fatima P. [4] ; Rahal, Paula [4] ; Zanetta, Dirce M. T. [5, 6]
Total Authors: 7
Affiliation:
[1] Fac Med Sao Jose Rio Preto FAMERP, Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas IBILCE, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Estadual Paulista, Microbiol IBILCE, Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Estadual Paulista, IBILCE, Sao Jose Do Rio Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Saude Publ, Sao Paulo - Brazil
[6] FAMERP, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Jornal de Pediatria; v. 87, n. 3, p. 219-224, MAY-JUN 2011.
Web of Science Citations: 13
Abstract

Objective: To evaluate the prevalence and seasonality of human respiratory syncytial virus (HRSV) in children aged 0 to 6 years, hospitalized with acute lower respiratory infection (ALRI) in Sao Jose do Rio Preto, SP, Brazil, and the association between age, diagnosis, and HRSV. Methods: Between May 2004 and September 2005, we studied 290 consecutive episodes of community-acquired ALRI in children aged 0 to 6 years admitted to the Hospital de Base of Sao Jose do Rio Preto. In order to detect HRSV, nasopharyngeal secretion samples were collected and RT-PCR molecular analysis was performed. Results: The HRSV prevalence was 29.3% for the cases of hospitalized patients with ALRI. ALRI was common in infants (median age = 13.5 months). HRSV was more frequent in cases of bronchiolitis (64%) and during the first year of life (35%). Episodes of HRSV infection occurred between fall and spring, showing higher frequency in 2004 than in 2005. Clinical and radiological criteria were not sufficient to establish the diagnosis of infection with HRSV. Antibiotic therapy was used in 78.8% of episodes of HRSV. Conclusions: There was a high prevalence of HRSV in children aged 0 to 6 years who were hospitalized for ALRI, predominantly in younger patients or those with bronchiolitis. The circulation of the virus varied in the two years studied. Our results suggest the need for laboratory diagnosis of HRSV in the clinical practice. (AU)