| Full text | |
| Author(s): |
Donado-Pestana, Carlos M.
;
Vasconcelos, Amanda D.
;
Mantovam, Vinicius B.
;
de Lima, Gustavo C.
;
Rodrigues, Larissa
;
Barbeiro, Hermes, V
;
Fock, Ricardo
;
de Souza, Heraldo P.
;
Franco, Bernadette D. G. de M.
;
Fiamoncini, Jarlei
Total Authors: 10
|
| Document type: | Journal article |
| Source: | JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 143, p. 9-pg., 2025-09-01. |
| Abstract | |
Menopause induces physiological alterations predisposing women to the development of chronic diseases. The evaluation of postprandial responses allows for a comprehensive assessment of metabolism and biomarkers that may predispose to chronic disease risk. By applying a dietary challenge consisting of the ingestion of a liquid, energy-dense mixed meal, followed by blood sampling over a 6-hour period, we conducted a cross-sectional study to investigate the postprandial metabolism in postmenopausal women (PM) aged 50-70 years and women of reproductive age (RA) aged 20 and 40 years. PM body weight was only 10% higher than RA, but the first displayed twice as much (more than 20%) intrabdominal adipose tissue. PM also displayed elevated fasting and postprandial glycemia (similar to 20%) and lipidemia compared to RA. Differences were also observed in the postprandial levels of lactate. Both groups displayed a similar increase in white blood cell count during the challenge, despite large differences in peripheral blood mononuclear cells (PBMC) gene expression in both fasting and postprandial states, suggesting a pro-inflammatory state and HIF-alpha and glycolytic pathway activation in PM. Plasma levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) were increased in PM (37 and 52%, respectively). Postprandial plasma levels of incretins presented different kinetics to each group. Our findings reveal that PM display a proinflammatory signature and markers of metabolic deterioration after a 12-h fasting and in the postprandial period when compared to RA. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU) | |
| FAPESP's process: | 23/02522-6 - Characterization of the postprandial profile of endocannabinoids in women: Effects of aging |
| Grantee: | Vinicius Bonfieti Mantovam |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 21/09237-0 - Postprandial metabolism and inflammation: the role of bile acids as signaling molecules |
| Grantee: | Larissa Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 22/02941-6 - Bile acids as determinants of postprandial metabolism and intestinal microbial colonization in newborns |
| Grantee: | Jarlei Fiamoncini |
| Support Opportunities: | Research Grants - Initial Project |
| FAPESP's process: | 22/08109-0 - Evaluation of the aging effects on postprandial responses: comparison between reproductive-age and postmenopausal women. |
| Grantee: | Amanda Domingos Vasconcelos |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 20/16542-0 - Relationship between inflammation and primary metabolism in the postprandial period |
| Grantee: | Carlos Mario Donado Pestana |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |