Synthesis of (2S)-isopropyl-5-alkynylpyrimidin-2-ones: precursors of beta-aminoacids

Stefani, Helio A.; Amaral, Monica F. Z. J.; Juaristi, Eusebio

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis of (2S)-isopropyl-5-alkynylpyrimidin-2-ones: precursors of beta-aminoacids

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Author(s):	Stefani, Helio A. ^[1] ; Amaral, Monica F. Z. J. ^[1] ; Juaristi, Eusebio ^[2] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo - Brazil ^[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Mexico City 07000, DF - Mexico Total Affiliations: 2
Document type:	Journal article
Source:	Tetrahedron Letters; v. 52, n. 9, p. 1014-1019, MAR 2 2011.
Web of Science Citations:	0
Abstract
The efficient palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of (2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-one with, arylethynyl-, heteroarylethynyl-, and alkylethynyltrifluoroborate salts is reported. The standard protocol was evaluated and optimized in order to gain access to suitable precursors of enantiopure 2-substituted beta-amino acids. The scope and limitations of this methodology are discussed. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

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