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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

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Author(s):
Sanches, Priscila de Lima [1] ; de Mello, Marco Tulio [2, 1] ; Elias, Natalia ; Helfenstein Fonseca, Francisco Antonio [3] ; de Piano, Aline [1] ; Carnier, June [1] ; Oyama, Lila Missae [4, 1] ; Tock, Lian [1] ; Tufik, Sergio [2] ; Damaso, Ana Raimunda [5, 1]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: HYPERTENSION RESEARCH; v. 34, n. 2, p. 232-238, FEB 2011.
Web of Science Citations: 26
Abstract

The aim of this study was to verify whether a 1-year interdisciplinary weight-loss program improved common carotid artery intima-media thickness (IMT) and whether insulin resistance and/or inflammation (as measured by the markers plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in adolescents. A group of 29 post-pubescent obese adolescents were submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery IMT was determined ultrasonographically. Body composition, blood pressure (BP), glycemia, insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and after the intervention. The interdisciplinary weight-loss program promoted a significant improvement in body composition, insulin concentration, HOMA-IR, lipid profile, BP and inflammatory state, in addition to significantly decreasing the common carotid artery IMT. Furthermore, this study demonstrated that the difference between baseline and final values of HOMA-IR (Delta HOMA-IR) was negatively correlated with concomitant changes in the adiponectin concentration (Delta adiponectin; r=-0.42; P=0.02) and positively correlated with changes in common carotid artery IMT (Delta carotid IMT; r=0.41; P=0.03). Multiple regression analysis adjusted by age, cardiovascular risk factors and inflammatory markers showed that Delta HOMA-IR was an independent predictor of significant changes in common carotid artery IMT. This investigation demonstrated that an interdisciplinary weight-loss program promoted a reduction of the common carotid artery IMT in obese Brazilian adolescents, and the improvement of HOMA-IR was an independent predictor of carotid IMT changes in this population. Hypertension Research (2011) 34, 232-238; doi: 10.1038/hr.2010.225; published online 2 December 2010 (AU)

FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants