Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program

Author(s)

Sanches, Priscila de Lima ^[1] ; de Mello, Marco Tulio ^{[2, 1]} ; Elias, Natalia ; Helfenstein Fonseca, Francisco Antonio ^[3] ; de Piano, Aline ^[1] ; Carnier, June ^[1] ; Oyama, Lila Missae ^{[4, 1]} ; Tock, Lian ^[1] ; Tufik, Sergio ^[2] ; Damaso, Ana Raimunda ^{[5, 1]}

Affiliation

^[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil

• Document type: Journal article
• Source: HYPERTENSION RESEARCH; v. 34, n. 2, p. 232-238, FEB 2011.
• Web of Science Citations: 26

Abstract

The aim of this study was to verify whether a 1-year interdisciplinary weight-loss program improved common carotid artery intima-media thickness (IMT) and whether insulin resistance and/or inflammation (as measured by the markers plasminogen activator inhibitor type-1 and adiponectin) might underlie obesity in adolescents. A group of 29 post-pubescent obese adolescents were submitted to an interdisciplinary intervention over the course of 1 year. Common carotid artery IMT was determined ultrasonographically. Body composition, blood pressure (BP), glycemia, insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile and adipokine concentrations were analyzed before and after the intervention. The interdisciplinary weight-loss program promoted a significant improvement in body composition, insulin concentration, HOMA-IR, lipid profile, BP and inflammatory state, in addition to significantly decreasing the common carotid artery IMT. Furthermore, this study demonstrated that the difference between baseline and final values of HOMA-IR (Delta HOMA-IR) was negatively correlated with concomitant changes in the adiponectin concentration (Delta adiponectin; r=-0.42; P=0.02) and positively correlated with changes in common carotid artery IMT (Delta carotid IMT; r=0.41; P=0.03). Multiple regression analysis adjusted by age, cardiovascular risk factors and inflammatory markers showed that Delta HOMA-IR was an independent predictor of significant changes in common carotid artery IMT. This investigation demonstrated that an interdisciplinary weight-loss program promoted a reduction of the common carotid artery IMT in obese Brazilian adolescents, and the improvement of HOMA-IR was an independent predictor of carotid IMT changes in this population. Hypertension Research (2011) 34, 232-238; doi: 10.1038/hr.2010.225; published online 2 December 2010 (AU)

• FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants