Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids

Full text
Author(s):
Maistro, E. L. [1] ; Angeli, J. P. F. [2] ; Andrade, S. F. [3] ; Mantovani, M. S. [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, UNESP, Marilia, SP - Brazil
[2] Univ Estadual Londrina, Dept Biol Geral, Londrina, PR - Brazil
[3] Univ Vale Itajai, Nucleo Invest Quim Farmaceut, Itajai, SC - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Genetics and Molecular Research; v. 10, n. 2, p. 1130-1140, 2011.
Web of Science Citations: 20
Abstract

Phenols are a large and diverse class of compounds, many of which occur naturally in a variety of food plants; they exhibit a wide range of biological effects, including antibacterial, anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, anticarcinogenic, and vasodilatory actions. We examined the genotoxic and clastogenic potential of three phenolic compounds: caffeic, cinnamic and ferulic acids, using the comet and micronucleus assays in vitro. Drug-metabolizing rat hepatoma tissue cells (HTCs) were used. Three different concentrations (50, 500 and 1500 mu M) of these phenolic acids were tested on the HTCs for 24 h. The caffeic, cinnamic and ferulic acids were not genotoxic by the comet assay (P > 0.05). However, the micronucleus test showed an increase in the frequency of micronucleated cells for the three compounds, indicating that these substances have clastogenic effects in HTC. (AU)