Biodegradable polymeric microparticles containing caffeic acid for dermal application

• Grant number: 15/02619-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): October 01, 2015
• Effective date (End): June 30, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marcos Antonio Corrêa
• Grantee: Caroline Magnani Spagnol
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 16/06742-7 - Release and permeation studies of topical formulations containing caffeic acid., BE.EP.DR

Abstract

Phenolic compounds are abundant in the Brazilian plant kingdom and they are part of a large and complex group of organic substances. Cinnamic acids are part of this group of organic compounds, and caffeic acid is one of the representatives. Besides powerful antioxidant activity, increasing collagen production and preventing premature aging, caffeic acid has demonstrated antimicrobial activity and may be promising in the treatment of dermal diseases. One of the applications of caffeic acid is in emulsions, which are widely used by consumers for pleasant and refreshing sensory, however, preparations developed in form of film or dry film are presented as an alternative technology for its ease and safety in transportation. To overcome the skin barrier, micro- and nanostructured systems have been developed to facilitate the delivery of active making it available to the tissue for a prolonged period of time without damage or toxicity. The objective of this study is to obtain biodegradable chitosan microparticles containing caffeic acid for dermal administration. Thus, chitosan microparticles containing caffeic acid will be obtained by spray drying and physical-chemically characterized, then they will be incorporated into an emulsion and a cosmetic preparation in film. The antimicrobial and antioxidant activity of caffeic acid will be determined, and finally we will assess the in vitro release profile, permeation and retention of microparticles of caffeic acid from the film and emulsion.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SPAGNOL, CAROLINE MAGNANI; ASSIS, RENATA PIRES; BRUNETTI, IGUATEMY LOURENCO; BORGES ISAAC, VERA LUCIA; NUNES SALGADO, HERIDA REGINA; CORREA, MARCOS ANTONIO. In vitro methods to determine the antioxidant activity of caffeic acid. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 219, p. 358-366, AUG 5 2019. (15/02619-3)

OLIVEIRA DOS SANTOS, LIA CAROLINA; SPAGNOL, CAROLINE MAGNANI; JOSE GUILLOT, ANTONIO; MELERO, ANA; CORREA, MARCOS ANTONIO. Caffeic acid skin absorption: Delivery of microparticles to hair follicles. SAUDI PHARMACEUTICAL JOURNAL, v. 27, n. 6, p. 791-797, SEP 2019. (15/02619-3, 16/07496-0, 17/07052-7)

SPAGNOL, CAROLINE M.; DI FILIPPO, LEONARDO D.; ISAAC, VERA L. B.; CORREA, MARCOS A.; SALGADO, HERIDA R. N.. Caffeic Acid in Dermatological Formulations: In Vitro Release Profile and Skin Absorption. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, v. 20, n. 8, p. 675-681, 2017. (15/02619-3)

DI FILIPPO, LEONARDO DELELLO; DUARTE, JONATAS LOBATO; ROQUE-BORDA, CESAR AUGUSTO; PAVAN, FERNANDO ROGERIO; MENEGUIN, ANDREIA BAGLIOTTI; CHORILLI, MARLUS; MELERO, ANA; GUILLOT, ANTONIO JOSE; SPAGNOL, CAROLINE MAGNANI; CORREA, MARCOS ANTONIO. In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide. LIFE-BASEL, v. 12, n. 7, p. 14-pg., 2022-07-01. (19/25125-7, 15/19097-0, 16/20957-6, 15/02619-3, 20/16573-3)

SPAGNOL, CAROLINE MAGNANI; MELERO ZAERA, ANA; BORGES ISAAC, VERA LUCIA; CORREA, MARCOS ANTONIO; NUNES SALGADO, HERIDA REGINA. Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid. SAUDI PHARMACEUTICAL JOURNAL, v. 26, n. 3, p. 410-415, MAR 2018. (16/06742-7, 15/02619-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SPAGNOL, Caroline Magnani. Micropartículas poliméricas biodegradáveis contendo ácido cafeico para aplicação tópica. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.