| Full text | |
| Author(s): |
Pereira, Marilia G. A. G.
[1]
;
Becari, Christiane
[2]
;
Oliveira, Jose A. C.
[2]
;
Salgado, Maria Cristina O.
[3]
;
Garcia-Cairasco, Norberto
[2]
;
Costa-Neto, Claudio M.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Clinical Science; v. 119, n. 11-12, p. 477-482, DEC 2010. |
| Web of Science Citations: | 38 |
| Abstract | |
The RAS (renin angiotensin system) is classically involved in BP (blood pressure) regulation and water electrolyte balance, and in the central nervous system it has been mostly associated with homoeostatic processes, such as thirst, hormone secretion and thermoregulation. Epilepsies are chronic neurological disorders characterized by recurrent epileptic seizures that affect 1-3% of the world's population, and the most commonly used anticonvulsants are described to be effective in approx. 70% of the population with this neurological alteration. Using a rat model of epilepsy, we found that components of the RAS, namely ACE (angiotensin-converting enzyme) and the AT(1) receptor (angiotensin II type I receptor) are up-regulated in the brain (2.6- and 8.2-fold respectively) following repetitive seizures. Subsequently, epileptic animals were treated with clinically used doses of enalapril, an ACE inhibitor, and losartan, an AT(1) receptor blocker, leading to a significant decrease in seizure severities. These results suggest that centrally acting drugs that target the RAS deserve further investigation as possible anticonvulsant agents and may represent an additional strategy in the management of epileptic patients. (AU) | |
| FAPESP's process: | 05/56447-7 - Research through images from high field magnetic resonance aimed at studies in humans |
| Grantee: | João Pereira Leite |
| Support Opportunities: | Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants |
| FAPESP's process: | 02/09406-5 - Neuro-humoral regulation of the cadiovascular system in physiological and physiopathological conditions |
| Grantee: | Maria Cristina de Oliveira Salgado |
| Support Opportunities: | Research Projects - Thematic Grants |