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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical Investigation of the Efficacy of Chemomechanical Preparation with Rotary Nickel-Titanium Files for Removal of Endotoxin from Primarily Infected Root Canals

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Author(s):
Martinho, Frederico C. [1] ; Chiesa, Wanderson M. M. [1] ; Marinho, Ariane C. S. [1] ; Zaia, Alexandre A. [1] ; Ferraz, Caio C. R. [1] ; Almeida, Jose E. A. [1] ; Souza-Filho, Francisco J. [1] ; Gomes, Brenda P. F. A. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Endodont Div, Dept Restorat Dent, Piracicaba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ENDODONTICS; v. 36, n. 11, p. 1766-1769, NOV 2010.
Web of Science Citations: 31
Abstract

Introduction: This clinical study was conducted to investigate the ability of chemomechanical preparation with 25% NaOCl + 17% ethylenediaminetetraacetic acid (EDTA) and rotary nickel-titanium (NiTi) system in removing endotoxin from primary root canal infection with apical periodontitis. Methods: Twenty-one root canals with necrotic pulps were selected. Samples were collected before (s1) and after chemomechanical preparation (s2). The limulus amebocyte lysate (LAL) assay was used to quantify endotoxins. Results: The LAL assay indicated that endotoxins were present in 100% of the root canals investigated (19/19) before (s1) and after chemomechanical preparation (s2). Analyses of the quantitative data revealed that the endotoxin content was significantly reduced at s2 (98.06%) compared with that at Si (P < .05). Conclusions: Our findings indicate that chemomechanical preparation with 2.5% NaOCl + 17% EDTA and rotary NiTi files was effective in reducing endotoxin load in the root canal infection from primarily infected teeth with apical periodontitis. (1 Endod 2010;36:1766-1769) (AU)