Atenolol blunts blood pressure increase during dynamic resistance exercise in hypertensives

Author(s)

Gomides, Ricardo S. ^[1] ; Costa, Luiz A. R. ^[1] ; Souza, Dinoelia R. ^[1] ; Queiroz, Andreia C. C. ^[1] ; Fernandes, Joao R. C. ^[2] ; Ortega, Katia C. ^[2] ; Mion Junior, Decio ^[2] ; Tinucci, Tais ^{[2, 1]} ; Forjaz, Claudia L. M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Exercise Hemodynam Lab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Gen Hosp, Hypertens Unit, Sao Paulo - Brazil

• Document type: Journal article
• Source: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY; v. 70, n. 5, p. 664-673, NOV 2010.
• Web of Science Citations: 6

Abstract

center dot Dynamic resistance exercise promotes a sizeable increase in blood pressure during its execution in non medicated hypertensives. WHAT THIS STUDY ADDS center dot Atenolol not only decreases blood pressure level but also mitigates the increase of blood pressure during dynamic resistance exercise in hypertensive patients. An increase in blood pressure during resistance exercise might be at least in part attributed to an increase in cardiac output. AIMS This study was conducted to determine whether atenolol was able to decrease BP level and mitigate BP increase during dynamic resistance exercise performed at three different intensities in hypertensives. METHODS Ten essential hypertensives (systolic/diastolic BP between 140/90 and 160/105 mmHg) were blindly studied after 6 weeks of placebo and atenolol. In each phase, volunteers executed, in a random order, three protocols of knee-extension exercises to fatigue: (i) one set at 100% of 1 RM; (ii) three sets at 80% of 1 RM; and (iii) three sets at 40% of 1 RM. Intra-arterial radial blood pressure was measured throughout the protocols. RESULTS Atenolol decreased systolic BP maximum values achieved during the three exercise protocols (100% = 186 +/- 4 vs. 215 +/- 7, 80% = 224 +/- 7 vs. 247 +/- 9 and 40% = 223 +/- 7 vs. 252 +/- 16 mmHg, P < 0.05). Atenolol also mitigated an increase in systolic BP in the first set of exercises (100% = +38 +/- 5 vs. +54 +/- 9; 80% = +68 +/- 11 vs. +84 +/- 13 and 40% = +69 +/- 7 vs. +84 +/- 14, mmHg, P < 0.05). Atenolol decreased diastolic BP values and mitigated its increase during exercise performed at 100% of 1 RM (126 +/- 6 vs. 145 +/- 6 and +41 +/- 6 vs. +52 +/- 6, mmHg, P < 0.05), but not at the other exercise intensities. CONCLUSIONS Atenolol was effective in both reducing systolic BP maximum values and mitigating BP increase during resistance exercise performed at different intensities in hypertensive subjects. (AU)

• FAPESP's process: 06/06356-8 - Blood pressure responses during resistance exercise in hypertensive patients: influence of beta-blockers
• Grantee: Cláudia Lúcia de Moraes Forjaz
• Support Opportunities: Regular Research Grants