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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi

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Author(s):
Regasini, Luis Octavio [1] ; Pivatto, Marcos [1] ; Scorzoni, Liliana [2] ; Benaducci, Tatiane [2] ; Fusco-Almeida, Ana Marisa [2] ; Soares Mendes Giannini, Maria Jose [2] ; Barreiro, Eliezer Jesus [3] ; Siqueira Siva, Dulce Helena [1] ; Bolzani, Vanderlan da Silva [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP - Brazil
[2] Univ Estadual Paulista, Dept Anal Clin & Toxicol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil
[3] Univ Fed Rio de Janeiro, Fac Farm, Ctr Ciencias Saude, BR-21944910 Rio De Janeiro - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 20, n. 5, p. 706-711, OCT-NOV 2010.
Web of Science Citations: 15
Abstract

As part of our ongoing research on antifungal agents from Brazilian flora, eight extracts and twelve fractions from Pterogyne nitens Tul., Fabaceae, were screened for antimicrobial activity against four opportunistic fungi species (Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans) using a broth microdilution method. The present investigation reveals that P. nitens extracts and fractions were more effective against C. krusei and C. parapsilosis than against C. neoformans. The growth of C. albicans was moderately affected by all tested extracts and fractions. The strongest effects were observed for n-butanol fractions from branches (MIC = 15.6 μg/mL) and roots (MIC = 31.2 μg/mL) against C. krusei. Additionally, the chromatographic fractionation of the n-butanol fraction from branches afforded four guanidine alkaloids; N-1,N-2,N-3-triisopentenylguanidine (1), described for the first time in the Fabaceae family, and nitensidines A-C (2-4), which showed moderate activity towards C. krusei (MIC = 62.5 μg/mL) and C. parapsilosis (MIC = 31.2 μg/mL). (AU)

FAPESP's process: 04/07932-7 - Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest
Grantee:Dulce Helena Siqueira Silva
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants