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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents

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Rando, Daniela Goncalves [1] ; Giarolla, Jeanine [1] ; Mesquita Pasqualoto, Kerly Fernanda [1] ; Ferreira, Elizabeth Igne [1]
Total Authors: 4
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Agents Potentia, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 46, n. 2, p. 311-321, APR-JUN 2010.
Web of Science Citations: 3

Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro assays. Since these chemical classes of compounds also resemble each other structurally, it would be useful to investigate whether they share direct analogy. Exploratory data analysis was applied to a library of chalcones and nitrated N-acylhydrazones assayed against Leishmania donovani to investigate their similarity. Under the conditions applied in the present study, the two classes did not present functional or structural analogy. (AU)

FAPESP's process: 01/01192-3 - Potential antitripanosomal derived from nitro-heterocyclic compounds
Grantee:Elizabeth Igne Ferreira
Support type: Research Projects - Thematic Grants