Synthesis of chalcones and their aryl analogues as potential alpha-glucosidase inh...
| Full text | |
| Author(s): |
Rando, Daniela Goncalves
[1]
;
Giarolla, Jeanine
[1]
;
Mesquita Pasqualoto, Kerly Fernanda
[1]
;
Ferreira, Elizabeth Igne
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Agents Potentia, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Pharmaceutical Sciences; v. 46, n. 2, p. 311-321, APR-JUN 2010. |
| Web of Science Citations: | 3 |
| Abstract | |
Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro assays. Since these chemical classes of compounds also resemble each other structurally, it would be useful to investigate whether they share direct analogy. Exploratory data analysis was applied to a library of chalcones and nitrated N-acylhydrazones assayed against Leishmania donovani to investigate their similarity. Under the conditions applied in the present study, the two classes did not present functional or structural analogy. (AU) | |
| FAPESP's process: | 01/01192-3 - Potential antitripanosomal derived from nitro-heterocyclic compounds |
| Grantee: | Elizabeth Igne Ferreira |
| Support type: | Research Projects - Thematic Grants |