Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

Full text
Author(s):
Grecco, Simone S. [1] ; Reimao, Juliana Q. [2] ; Tempone, Andre G. [2] ; Sartorelli, Patricia [1] ; Romoff, Paulete [3, 4] ; Ferreira, Marcelo J. P. [3, 4] ; Favero, Oriana A. [3, 4] ; Lago, Joao H. G. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP - Brazil
[2] Inst Adolfo Lutz Registro, Div Biol Med, Serv Parasitol, Lab Toxinol Aplicada, BR-01246000 Sao Paulo - Brazil
[3] Univ Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, BR-01302907 Sao Paulo - Brazil
[4] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Parasitology Research; v. 106, n. 5, p. 1245-1248, APR 2010.
Web of Science Citations: 37
Abstract

In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry. (AU)

FAPESP's process: 06/57626-5 - Selection of potential molecules in plant species of São Paulo State highlands: chemical structure, relationship structure / biological activity associated with ecophysiological considerations
Grantee:João Henrique Ghilardi Lago
Support Opportunities: Research Grants - Young Investigators Grants