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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Furosemide impairs nasal mucociliary clearance in humans

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Author(s):
Goto, Danielle M. [1, 2] ; Torres, Giuliana M. [2] ; Seguro, Antonio C. [3] ; Saldiva, Paulo H. N. [1] ; Lorenzi-Filho, Geraldo [4] ; Nakagawa, Naomi K. [1, 2, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med, LIM 05, Dept Pathol, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, LIM 34, Dept Physiotherapy Commun Sci & Disorders, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, LIM 12, Dept Nephrol, BR-01246903 Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Inst Heart, Div Pulm, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 170, n. 3, p. 246-252, MAR 31 2010.
Web of Science Citations: 6
Abstract

Furosemide, a potent diuretic, affects ion and water movement across the respiratory epithelium. However, the effects of furosemide, as clinically used, on mucociliary clearance, a critical respiratory defense mechanism, are still lacking in humans. Fourteen young healthy subjects were assigned to three random interventions, spaced one-week apart: no intervention (control), oral furosemide (40 mg), and furosemide + oral volume replacement (F + R). Nasal mucociliary clearance was assessed by saccharine test (STT), and mucus properties were in vitro evaluated by means of contact angle and transportability by sneeze. Urine output and osmolality were also evaluated. Urine output increased and reduced urine osmolality in furosemide and F + R compared to the control condition. STT remained stable in the control group. In contrast, STT increased significantly (40%) after furosemide and F + R. There were no changes in vitro mucus properties in all groups. In conclusion, furosemide prolongs STT in healthy young subjects. This effect is not prevented by fluid replacement, suggesting a direct effect of furosemide on the respiratory epithelium. (C) 2010 Elsevier B.V. All rights reserved. (AU)