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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis and rational design of anti-inflammatory compounds: N-phenyl-cyclohexenyl sulfonamide derivatives

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Author(s):
Lloret, Gustavo R. [1] ; Cunha Neto, Alvaro [1] ; Rittner, Roberto [1] ; Bitencourt, Michelle [1] ; Freitas, Matheus P. [2] ; Aquino, Nilton S. [3]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Inst Chem, BR-13084971 Sao Paulo - Brazil
[2] Univ Fed Lavras, Dept Quim, UFLA, BR-37200000 Lavras, MG - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, BR-13081971 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY; v. 22, n. 12, p. 1188-1192, DEC 2009.
Web of Science Citations: 4
Abstract

The synthesis of (+/-)-ethyl 6-{[}N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (5n) has been reproduced from a method previously described and served as the background for the preparation of a nitro derivative, potentially useful as an anti-inflammatory agent. Furthermore, a structure-based QSAR analysis of a series of N-arylsulfamoyl congeners derived a highly predictive model for the activities of novel small-molecule inhibitors of NO and cytokine production, whose preparation may be successfully achieved according to a similar procedure as above. Copyright (C) 2009 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 05/59649-0 - Conformational equilibria studies by nuclear magnetic resonance spectroscopy, infrared spectroscopy and theoretical calculations
Grantee:Roberto Rittner Neto
Support Opportunities: Research Projects - Thematic Grants