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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regulation of Radial Glial Motility by Visual Experience

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Author(s):
Tremblay, Marc [1, 2, 3] ; Fugere, Vincent [4] ; Tsui, Jennifer [1, 2] ; Schohl, Anne [1] ; Tavakoli, Aydin [1, 2, 3] ; Travencolo, Bruno A. N. [5] ; Costa, Luciano da F. [5] ; Ruthazer, Edward S. [1, 2, 3, 4]
Total Authors: 8
Affiliation:
[1] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4 - Canada
[2] McGill Univ, Montreal Neurol Inst, McGill Program NeuroEngn, Montreal, PQ H3A 2B4 - Canada
[3] McGill Univ, Montreal Neurol Inst, McGill Grad Program Neurosci, Montreal, PQ H3A 2B4 - Canada
[4] McGill Univ, Montreal Neurol Inst, Dept Psychol, Montreal, PQ H3A 2B4 - Canada
[5] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF NEUROSCIENCE; v. 29, n. 45, p. 14066-14076, NOV 11 2009.
Web of Science Citations: 21
Abstract

Radial glia in the developing optic tectum express the key guidance molecules responsible for topographic targeting of retinal axons. However, the extent to which the radial glia are themselves influenced by retinal inputs and visual experience remains unknown. Using multiphoton live imaging of radial glia in the optic tectum of intact Xenopus laevis tadpoles in conjunction with manipulations of neural activity and sensory stimuli, radial glia were observed to exhibit spontaneous calcium transients that were modulated by visual stimulation. Structurally, radial glia extended and retracted many filopodial processes within the tectal neuropil over minutes. These processes interacted with retinotectal synapses and their motility was modulated by nitric oxide (NO) signaling downstream of neuronal NMDA receptor (NMDAR) activation and visual stimulation. These findings provide the first in vivo demonstration that radial glia actively respond both structurally and functionally to neural activity, via NMDAR-dependent NO release during the period of retinal axon ingrowth. (AU)

FAPESP's process: 05/00587-5 - Mesh (graph) modeling and techniques of pattern recognition: structure, dynamics and applications
Grantee:Roberto Marcondes Cesar Junior
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 07/02938-5 - Computational methods for characterization and analysis of neurons and glias
Grantee:Bruno Augusto Nassif Travençolo
Support Opportunities: Scholarships in Brazil - Post-Doctoral