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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metabolic osteopathy in celiac disease: importance of a gluten-free diet

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Author(s):
Capriles, Vanessa D. [1] ; Martini, Ligia A. [1] ; Areas, Jose Alfredo G. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: NUTRITION REVIEWS; v. 67, n. 10, p. 599-606, OCT 2009.
Web of Science Citations: 34
Abstract

Reduced bone mineral density (BMD) is frequently found in individuals with untreated celiac disease (CD), possibly due to calcium and vitamin D malabsorption, release of pro-inflammatory cytokines, and misbalanced bone remodeling. A gluten-free diet (GFD) promotes a rapid increase in BMD that leads to complete recovery of bone mineralization in children. Children may attain normal peak bone mass if the diagnosis is made and treatment is given before puberty, thereby preventing osteoporosis in later life. A GFD improves, but rarely normalizes, BMD in patients diagnosed with CD in adulthood. In some cases, nutritional supplementation may be necessary. More information on therapeutic alternatives is needed. (AU)