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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Najera oxime-derived palladacycles catalyze intermolecular Heck reaction with Morita-Baylis-Hillman adducts. An improved and highly efficient synthesis of alpha-benzyl-beta-ketoesters

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Author(s):
Ferreira, Bruno R. V. [1] ; Pirovani, Rodrigo V. [1] ; Souza-Filho, Luis G. [1] ; Coelho, Fernando [1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Lab Synth Nat Prod & Drugs, Inst Chem, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Tetrahedron; v. 65, n. 36, p. 7712-7717, SEP 5 2009.
Web of Science Citations: 20
Abstract

An improved and highly efficient synthesis of several alpha-benzyl-beta-ketoesters from Morita-Baylis-Hillman adducts is described. These adducts were used as substrates for an intermolecular Heck reaction catalyzed by a Najera oxime-derived palladacycles. These efficient catalytic conditions probed to be very selective providing only the corresponding functionalized beta-ketoesters in high yield with no decarboxylation product. It seems that the method herein described is one of the most efficient for the synthesis of alpha-benzyl-beta-ketoesters. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 06/06347-9 - Synthesis of Drugs and bioactive substances from Morita-Baylis-Hillman adducts
Grantee:Fernando Antonio Santos Coelho
Support Opportunities: Regular Research Grants