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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment with an anti-inflammatory drug is detrimental for muscle regeneration at Bothrops jararacussu envenoming: An experimental study

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Author(s):
Vomero, Viviane Urbini [1] ; Marques, Maria Julia [1] ; Neto, Humberto Santo [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Dept Anat, Inst Biol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Toxicon; v. 54, n. 3, p. 361-363, SEP 1 2009.
Web of Science Citations: 7
Abstract

We evaluated the effects of deflazacort (DFZ) on muscle regeneration following Bothrops jararacussu envenoming. Tibialis anterior muscle from adult mice was injected with 80 mu g of venom. Animals received DFZ during 6 days. Seven and 60 days after envenoming, DFZ lead to a decrease in the total number of muscle fibers and an increase in interstitial fibrosis. We conclude that DFZ treatment may aggravate the loss of muscle mass after B. jararacussu envenoming. (C) 2009 Elsevier Ltd. All rights reserved. (AU)