Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey

Author(s):Show less -

Andreoli, Sergio Baxter ^[1] ; Ribeiro, Wagner Silva ^[1] ; Quintana, Maria Ines ^[1] ; Guindalini, Camila ^[1] ; Breen, Gerome ^[2] ; Blay, Sergio Luis ^[1] ; Coutinho, Evandro S. F. ^[3] ; Harpham, Trudy ^{[4, 5]} ; Jorge, Miguel Roberto ^[1] ; Lara, Diogo Rizzato ^[6] ; Moriyama, Tais S. ^[1] ; Quarantini, Lucas C. ^[1] ; Gadelha, Ary ^[1] ; Pereira Vilete, Liliane Maria ^[3] ; Yeh, Mary S. L. ^[1] ; Prince, Martin ^[7] ; Figueira, Ivan ^[8] ; Bressan, Rodrigo A. ^[1] ; Mello, Marcelo F. ^[1] ; Dewey, Michael E. ^[7] ; Ferri, Cleusa P. ^[7] ; Mari, Jair de Jesus ^{[1, 7]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[2] Kings Coll London, Inst Psychiat, MRC Social, London WC2R 2LS - England

^[3] ENSP FIOCRUZ, Rio De Janeiro - Brazil

^[4] London Sch Hyg & Trop Med, London WC1 - England

^[5] London S Bank Univ, London - England

^[6] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Porto Alegre, RS - Brazil

^[7] Univ London, Kings Coll, Inst Psychiat, Ctr Publ Mental Hlth, Hlth Serv & Populat Res Dept, London - England

^[8] Univ Fed Rio de Janeiro, IPUB, Inst Psychiat, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: BMC Psychiatry; v. 9, JUN 7 2009.
• Web of Science Citations: 26

Abstract

Background: violence is a public health major concern, and it is associated with post-traumatic stress disorder and other psychiatric outcomes. Brazil is one of the most violent countries in the world, and has an extreme social inequality. Research on the association between violence and mental health may support public health policy and thus reduce the burden of disease attributable to violence. The main objectives of this project were: to study the association between violence and mental disorders in the Brazilian population; to estimate the prevalence rates of exposure to violence, post-traumatic stress disorder, common metal disorder, and alcohol hazardous use and dependence: and to identify contextual and individual factors, including genetic factors, associated with the outcomes. Methods/design: one phase cross-sectional survey carried out in Sao Paulo and Rio de Janeiro, Brazil. A multistage probability to size sampling scheme was performed in order to select the participants (3000 and 1500 respectively). The cities were stratified according to homicide rates, and in Sao Paulo the three most violent strata were oversampled. The measurements included exposure to traumatic events, psychiatric diagnoses (CIDI 2.1), contextual (homicide rates and social indicators), and individual factors, such as demographics, social capital, resilience, help seeking behaviours. The interviews were carried between June/2007 February/2008, by a team of lay interviewers. The statistical analyses will be weight-adjusted in order to take account of the design effects. Standardization will be used in order to compare the results between the two centres. Whole genome association analysis will be performed on the 1 million SNP (single nucleotide polymorphism) arrays, and additional association analysis will be performed on additional phenotypes. The Ethical Committee of the Federal University of Sao Paulo approved the study, and participants who matched diagnostic criteria have been offered a referral to outpatient clinics at the Federal University of Sao Paulo and Federal University of Rio de Janeiro. (AU)

• FAPESP's process: 04/15039-0 - Post-traumatic stress disorder: epidemiology, physiopathology and treatment
• Grantee: Jair de Jesus Mari
• Support Opportunities: Research Projects - Thematic Grants