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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Phylogenetic classification of human papillomavirus genotypes in high-grade cervical intraepithelial neoplasia in women from a densely populated Brazilian urban region

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Author(s):
Pitta, Denise Rocha [1] ; Sarian, Luis Otavio [1] ; Campos, Elisabete Aparecida [1] ; Rabelo-Santos, Silvia Helena [2] ; Syrjanen, Kari [3] ; Derchain, Sophie Francoise [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Dept Obstet & Gynecol, Campinas, SP - Brazil
[2] Univ Fed Goias, Sch Pharm, Goiania, Go - Brazil
[3] Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20520 Turku - Finland
Total Affiliations: 3
Document type: Journal article
Source: São Paulo Medical Journal; v. 127, n. 3, p. 122-127, MAY 7 2009.
Web of Science Citations: 7
Abstract

CONTEXT AND OBJECTIVE: Differences in human papillomavirus (HPV) types may correlate with the biological potential and invasion risk of high-grade cervical intraepithelial neoplasia (CIN 2 and CIN 3). The objective of this study was to determine the relationship between different combinations of HPV types and CIN severity. DESIGN AND SETTING: Cross-sectional study, at Universidade Estadual de Campinas (Unicamp). METHODS: Cervical samples from 106 women treated due to CIN 2 (18) or CIN 3 (88) were examined for specific HPV genotypes using Roche Linear Array(R) (LA-HPV). The proportions of CIN 2 and CIN 3 in groups of women infected with the HPV phylogenetic groups A7 and A9 were compared. Three groups were formed: women with single infections; multiple infections; and the whole sample. RESULTS: Multiple infections were detected in 68 samples (64.7%). The most frequent high-risk genotypes detected (single/multiple) were HPV 16 (57.1%), HPV 58 (24.7%), HPV 33 (15.2%), HPV 52 (13.3%), HPV 31 (10.4%), HPV 51 (7.6%) and HPV 18 (6.6%). Women without infection with HPV species Alpha 9 were less likely to have CIN 3 than were their Alpha 9 HPV-infected counterparts. HPV 16 and/or HPV 18, with or without associations with other viral types, were more frequently found in women with CIN 3 than in those with CIN 2. CONCLUSIONS: The severity of high-grade CIN may be aggravated by the presence of HPV types included in the Alpha 9 phylogenetic classification and by infections including HPV 16 and 18, singly or in combination with other HPV genotypes. (AU)