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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanical properties and cytotoxicity of 3Y-TZP bioceramics reinforced with Al2O3 particles

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Author(s):
Santos, C. [1] ; Teixeira, L. H. P. [1] ; Daguano, J. K. M. F. [1] ; Rogero, S. O. [2] ; Strecker, K. [3] ; Elias, C. N. [4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Escola Engn Lorena, Dept Mat Engn, BR-12600000 Lorena, SP - Brazil
[2] IPEN CNEN SP, BR-05508900 Sao Paulo - Brazil
[3] UFSJ DEMEC, BR-36307352 Sj Del Rei, MG - Brazil
[4] IME, BR-22290270 Rio De Janeiro - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CERAMICS INTERNATIONAL; v. 35, n. 2, p. 709-718, MAR 2009.
Web of Science Citations: 28
Abstract

The influence of Al(2)O(3) addition and sintering parameters on the mechanical properties and cytotoxicity of tetragonal ZrO(2)-3 mol% Y(2)O(3) ceramics was evaluated. Samples containing 0, 10, 20 and 30 wt.% of Al(2)O(3) particles were prepared by cold uniaxial pressing (80 MPa) and sintered in air at 1500, 1550 and 1600 degrees C for 120 min. The effects of the sintering conditions on the microstructure were analyzed by X-ray diffraction analysis and scanning electron microscopy. Hardness and fracture toughness were determined by the Vickers indentation method and the mechanical resistance by four-point bending tests. As a preliminary biological evaluation, ``in vitro{''} cytotoxicity tests were realized to determine the cytotoxic level of the ZrO(2)-Al(2)O(3) composites, using the neutral red uptake method with NCTC clones L929 from the American Type Culture Collection (ATCC) bank. Fully dense ceramic materials were obtained with a hardness ranging between 1340 HV and 1585 HV, depending on the amount of Al(2)O(3) in the ZrO(2) matrix. On the other hand, no significant influence of the Al(2)O(3) addition on fracture toughness was observed, exhibiting values near 8 MPa m(1/2) for all compositions and sintering conditions studied. The non-cytotoxic behavior, the elevated fracture toughness, the good bending strength (sigma(f) = 690 MPa) and the elevated Weibull's modulus (m = 11) exhibited by the material, show that these ceramic composites are highly suitable biomaterials for dental implant applications. (C) 2008 Elsevier Ltd and Techna Group S.r.l. All rights reserved. (AU)