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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Vitamin D deficiency in patients with active systemic lupus erythematosus

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Author(s):
Borba, V. Z. C. [1, 2] ; Vieira, J. G. H. [1] ; Kasamatsu, T. [1] ; Radominski, S. C. [3] ; Sato, E. I. [4] ; Lazaretti-Castro, M. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Div Endocrinol, Sao Paulo - Brazil
[2] Univ Fed Parana, Div Endocrinol, Serv Endocrinol, SEMPR, BR-80060000 Curitiba, Parana - Brazil
[3] Univ Fed Parana, Div Rheumatol, BR-80060000 Curitiba, Parana - Brazil
[4] Univ Fed Sao Paulo, Div Rheumatol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: OSTEOPOROSIS INTERNATIONAL; v. 20, n. 3, p. 427-433, MAR 2009.
Web of Science Citations: 117
Abstract

We investigated the effects of disease activity on bone metabolism in 36 patients with systemic lupus erythematosus (SLE). Changes in bone remodeling were not explained by corticosteroid use. A high prevalence of 25OHD deficiency in SLE patients indicates the need for vitamin D replacement, mainly during high disease activity periods. We investigated the effects of SLE disease activity on bone metabolism, their relation to inflammatory cytokines and vitamin D levels. We performed a cross-sectional analysis of 36 SLE patients classified according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) in high activity (group I: 12 patients, mean age 29.6 years) or in minimal activity (group II: 24 patients, mean age 30.0 years), and compared them to normal controls (group III: 26 women, 32.8 years). Serum calcium, phosphorus, parathyroid and sex hormones, bone remodeling markers, interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), IL-1, tumor necrosis factor-alpha (TNF), 25-hydroxivitamin D (25OHD), and 1,25-dihydroxyvitamin D3 were measured, plus bone mineral density. All cytokines were significantly higher in SLE groups; IL-6 could differentiate SLE patients from controls. In group I, 25OHD levels were lower (P < 0.05), which was related to the SLEDAI (R = -0.65, P < 0.001). In multiple regression analysis, the 25OHD level was associated with SLEDAI, osteocalcin and bone-specific alkaline phosphatase. The SLEDAI score was positively correlated with all measured cytokines and especially TNF (R = 0.75, P < 0.001). SLE patients demonstrated changes in bone remodeling strongly related to disease activity. A high prevalence of 25OHD deficiency was observed in SLE patients, indicating the need for vitamin D replacement. (AU)

FAPESP's process: 97/02856-5 - Osteo-metabolic changes in systemic lupus erythematosus (SLE) in activity and their correlation with circulating cytokines, interleukin 1 (IL-1), 6 (IL-6), tumoral necrosis factor (TNF) and circulating soluble receptor of IL-6 (sIL-6R)
Grantee:Marise Lazaretti Castro
Support Opportunities: Regular Research Grants