Effects of type II pyrethroid cyhalothrin on rat innate immunity: A flow cytometric study

Author(s)

Righi, D. A. ^[1] ; Xavier, F. G. ^[2] ; Palermo-Neto, J. ^[2]

Affiliation

^[1] Univ Brasilia, Mol Pharmacol Lab, Sch Hlth Sci, Dept Pharmaceut Sci, Brasilia, DF - Brazil

^[2] Univ Sao Paulo, Sch Vet Med, Appl Pharmacol & Toxicol Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: International Immunopharmacology; v. 9, n. 1, p. 148-152, JAN 2009.
• Web of Science Citations: 14

Abstract

Synthetic type II pyrethroids induce anxiety, immunosuppresion or, alternatively, immunostimulatory effects in laboratory animals. Macrophages and neutrophils are known to be key elements in cellular immune responses. The present study was designed to investigate the in vivo effects of cyhalothrin (1.0 and 3.0 mg/kg/once daily for 7 days) on macrophage and neutrophil activities, using a flow cytometry method. Results showed that cyhalothrin treatment decreased the percentage and intensity of phagocytosis performed by macrophages, but did not alter these parameters in neutrophils: and also decreased basal neutrophil oxidative burst and increased S. aureus-induced neutrophil oxidative burst, but did not alter these responses in macrophages. The present results are discussed in the light of a possible indirect action of cyhalothrin on macrophage and neutrophil activities via hypothalamic pituitary adrenal (HPA) axis activation. A possible direct effect of cyhalothrin on macrophage and neutrophil activities is also considered. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 04/14128-0 - Neuroimmunomodulation: effects of drugs, stress and cytocines on central nervous and immune systems bidirectional relationships
• Grantee: João Palermo Neto
• Support Opportunities: Research Projects - Thematic Grants