Evaluation of the Analytical Potentialities of a Composite Electrode Modified with Molecularly Imprinted Polymers

Author(s)

Cervini, Priscila ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1]

Affiliation

^[1] Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13566390 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Analytical Letters; v. 42, n. 13, p. 1940-1957, 2009.
• Web of Science Citations: 9

Abstract

The preparation of a methacrylate polymer molecularly imprinted (MIP) with paracetamol (APAP) was performed. After extraction of the APAP template molecule, the MIPs were incorporated into a graphite-polyurethane (GPU) matrix, and the resulting composites were used to prepare modified electrodes intended to be used in APAP determination. The best results were found using a 2.5% MIP in the GPU electrode and a 500-mu m MIP particle size. This electrode was used in the determination of APAP in pharmaceutical formulations, reaching a 6.7x10-8mol L-1 limit of detection. The 2.5% MIP-GPU-modified electrode showed better sensitivity than the nonimprinted methacrylate GPU-modified electrodes. Interference of phenacetin in the APAP response decreased remarkably when the proposed electrode was used. (AU)

• FAPESP's process: 08/03537-7 - Development and application of composite electrodes based on graphite-poliurethane and graphite-silicone rubber-III: modification with carbon nanotubes and molecularly imprinted polymers
• Grantee: Éder Tadeu Gomes Cavalheiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 06/06133-9 - Development and application of graphite-polyurethane composite electrodes modified with polymers
• Grantee: Priscila Cervini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral