Angiogenic Properties of Natural Rubber Latex Biomembranes and The Serum Fraction of Hevea brasiliensis

Author(s)

Ferreira, Mariselma ^[1] ; Mendonca, Ricardo Jose ^[2] ; Coutinho-Netto, Joaquim ^[2] ; Mulato, Marcelo ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Fis & Matemat, FFCLRP, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Bioquim, FMRP, Sao Paulo - Brazil

• Document type: Journal article
• Source: Brazilian Journal of Physics; v. 39, n. 3, p. 564-569, 2009.
• Web of Science Citations: 40

Abstract

The angiogenic properties of natural rubber were evaluated in this work. We have used the chick chorioal-lantoic membrane assay (CAM) as a model to investigate the influence of the heating on biological activity in rubber membranes and in non rubber fraction as well. Results showed that natural rubber membranes can induce vascularization. It was observed that angiogenesis activity was maximum when membranes were heated in temperatures between 65 degrees C and 85 degrees C, considering a range from 55 degrees C to 105 degrees C. The same behavior was observed for non rubber fraction and it indicates that this serum fraction may be responsible for angiogenesis. When infrared spectroscopy was performed in the cast films of non rubber fraction samples, as a function of heating, no structural changes was observed. The results obtained shown that natural rubber latex films produced by casting induce the vessel growth in the CAM and it can be considered as a potential biomaterial. (AU)