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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Minor sperm abnormalities in young male post-pubertal patients with juvenile dermatomyositis

Full text
Author(s):
Moraes, A. J. P. [1] ; Pereira, R. M. R. [2] ; Cocuzza, M. [3] ; Casemiro, R. [1] ; Saito, O. [4] ; Silva, C. A. A. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med, Unidade Reumatol Pediat, Dept Pediat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Div Reumatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Div Urol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Div Radiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 41, n. 12, p. 1142-1147, DEC 2008.
Web of Science Citations: 14
Abstract

The objective of the present study was to identify sperm abnormalities in young male patients with juvenile dermatomyositis (JDM). In 2005, 18 male JDM patients, diagnosed according to the criteria of Bohan and Peter, were followed at the Pediatric Rheumatology Unit and Rheumatology Division, of our Institution. Of the 18 males, 11 were pre-pubertal and 7 were post-pubertal. Two of 7 post-pubertal JDM male patients were excluded: one for orchidopexy for cryptorchidism and the other for testicular ectopia in the left testis. The remaining 5 post-pubertal JDM patients were prospectively evaluated on the basis of two semen analyses, according to the World Health Organization (WHO), urologic evaluation, testicular Doppler ultrasound hormone profile. The data of the JDM patients were compared with those of 5 age-matched healthy controls. The median age 18, was similar in JDM patients and controls. All JDM patients had teratozoospermia (abnormal sperm morphology), as did 4 (80%) of the controls. One of JDM patients had previous oligoasthenoteratozoospermia treated with intravenous cyclophosphamide with normalization of the number and concentration of the sperm after 5 years. All sperm parameters (sperm concentration, total sperm count and total motile sperm count by WHO, and sperm morphology by Kruger strict criteria), testicular volumes by Prader orchidometer and ultrasound, and hormones were similar in JDM patients compared with controls. The frequency of anti-sperm antibodies was similar in both groups. All JDM patients had minor sperm abnormalities in the head, midpiece, and/or tail of spermatozoids. Serial semen analyses in larger study populations are necessary to identify the extent and duration of sperm abnormalities in male patients with idiopathic inflammatory myopathies. (AU)