| Full text | |
| Author(s): Show less - |
Nakandakare, Edna R.
[1]
;
Charf, Ana M.
[1]
;
Santos, Flavia C.
[1]
;
Nunes, Valeria S.
[1]
;
Ortega, Katia
[2]
;
Lottenberg, Ana M. P.
[1]
;
Mion, Jr., Decio
[2]
;
Nakano, Takamitsu
[3]
;
Nakajima, Katsuyuki
[3]
;
D'Amico, Elbio A.
[4]
;
Catanozi, Sergio
[1]
;
Passarelli, Marisa
[1]
;
Quintao, Eder C. R.
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Lipids Lab LIM10, Endocrinol & Metab Div, Hosp Clin, Fac Med Sci, BR-01246000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Hypertens Unit, Nephrol Div, Hosp Clin, Fac Med Sci, BR-01246000 Sao Paulo - Brazil
[3] Japan Immunores Labs Co Ltd, Takasaki, Gumma - Japan
[4] Hemoctr SP, Prosangue Fdn, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | ATHEROSCLEROSIS; v. 200, n. 2, p. 410-416, OCT 2008. |
| Web of Science Citations: | 28 |
| Abstract | |
Background: Dietary salt restriction has been reported to adversely modify the plasma lipoprotein profile in hypertensive and in normotensive subjects. We investigated the effects of the low sodium intake (LSI) on the plasma lipoprotein profile and on inflammation and thrombosis biomarkers during the fasting and postprandial periods. Methods: Non-obese, non-treated hypertensive adults (n=41) were fed strictly controlled diets. An initial week on a control diet (CID, Na=160 mmol/day) was followed by 3 weeks on LSI (Na=60mmol/day). At admission and on the last day of each period, the 24-h ambulatory blood pressure was monitored and blood was drawn after an overnight fasting period and after a fat-rich test meal. Results: The dietary adherence was confirmed by 24-h urinary sodium excretion. Fasting triglyceride (TG), chylomicron-cholesterol, hsC-reactive protein (CRP), tumor necrosis factor-a (TNF-alpha). interleukin-6 (IL-6) concentrations, renin activity, aldosterone, insulin, and homeostasis model assessment insulin resistance (HOMA-IR) Values were higher, but non-esterified fatty acids (NEFA) were lower on LSI than on CD. For LSI, areas under the curve (AUC) of TG, chylomicron-cholesterol, apoB and the cholesterol/apoB ratio were increased, whereas AUC-NEFA was lowered. LSI did not modify body weight, hematocrit, fasting plasma cholesterol, glucose, adiponectin, leptin, fibrinogen and factor VII (FVII), and AUC of lipoprotein lipase and of lipoprotein remnants. Conclusion: LSI induced alterations in the plasma lipoproteins and in inflammatory markers that are common features of the metabolic syndrome. (C) 2008 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 00/04249-3 - Influence of the salt deficient diet on atherosclerosis risk factors: measurements in the fasting and in the alimentary phases |
| Grantee: | Eder Carlos Rocha Quintão |
| Support Opportunities: | Research Projects - Thematic Grants |