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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prevalence and distribution of serotype-specific genotypes of Aggregatibacter actinomycetemcomitans in chronic periodontitis Brazilian subjects

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Author(s):
Goncalves Roman-Torres, Caio Vinicius [1] ; Aquino, Davi Romeiro [1] ; Cortelli, Sheila Cavalca [1] ; Nobre Franco, Gilson Cesar [1] ; dos Santos, Juliana Guimaraes [1] ; Corraini, Priscila [2] ; Holzhausen, Marinella [1] ; Diniz, Marina Goncalves [3] ; Gomez, Ricardo Santiago [3] ; Cortelli, Jose Roberto [1]
Total Authors: 10
Affiliation:
[1] Univ Taubate, Dept Periodontol & Prevent Dent, Dent Res Div, BR-12020330 Taubate, SP - Brazil
[2] Univ Sao Paulo, Div Periodont, Dept Stomatol, Sch Dent, BR-05508900 Sao Paulo - Brazil
[3] Univ Fed Minas Gerais, Dept Mol Biol, Sch Dent, BR-31270901 Belo Horizonte, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 55, n. 3, p. 242-248, MAR 2010.
Web of Science Citations: 17
Abstract

Objective: Previous studies have suggested that Aggregatibacter actinomycetemcomitans is involved in the aetiology of aggressive periodontitis as well as chronic periodontitis. In addition, some authors have also reported that serotype-specific antigens of A. actinomycetemcomitans determine the severity of disease. This study aimed to elucidate the prevalence of A. actinomycetemcomitans and the distribution of A. actinomycetemcomitans serotypes in Brazilian subjects with chronic periodontitis. Design: A total of 486 individuals were enrolled in this survey. All patients received clinical examinations that included periodontal pocket depth, clinical attachment loss, plaque, and gingival indexes. Subgingival samples were taken for microbial analysis. The genomic DNA of A. actinomycetemcomitans was provided by PCR. Results: Out of 486 subjects examined, A. actinomycetemcomitans was isolated in 85 (17.5%) individuals. Out of 85 positive samples, 68 were infected by at least 1 serotype, 7 by mixed infection, and 10 were non-serotyped. Serotypes d and f were not detected. Serotype c showed the highest prevalence (52.9%), followed by serotype a (31.8%). Conclusions: Intragroup analysis revealed that, in slight/moderate periodontitis, serotypes c and a were significantly more prevalent than serotypes b and d-f; the prevalence of serotype c in severe periodontitis was significantly greater than that of serotypes a and b. Our data were similar in Asian and Eurasian populations. (C) 2010 Elsevier Ltd. All rights reserved. (AU)