Using thermal and spectroscopic data to investigate the thermal behavior of epinephrine

Author(s)

Bannach, Gilbert ^[1] ; Cervini, Priscila ^[1] ; Gomes Cavalheiro, Eder Tadeu ^[1] ; Ionashiro, Massao ^[2]

Affiliation

^[1] USP, IQSC, BR-13560970 Sao Carlos, SP - Brazil

^[2] UNESP, Inst Quim, BR-14801970 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Thermochimica Acta; v. 499, n. 1-2, p. 123-127, FEB 20 2010.
• Web of Science Citations: 27

Abstract

Epinephrine is a neurotransmitter of the catecholamine class that acts in the mammalian central nervous system. The TG-DTA curves of epinephrine showed that the anhydrous compound starts decomposition at 165 degrees C, under the conditions used in this work. The reflectance FTIR spectra and X-ray powder diffraction patterns of epinephrine before and after heating up to 210 degrees C, as well as the TG-FTIR spectra of sample heated between 30 and 600 degrees C, were obtained and reveled that after heating, structural changes occurred in the sample. At temperatures higher than 205 degrees C the thermal decomposition took place with elimination of rnethylamine in agreement with the first mass loss observed in the TG curve in both air and N(2) atmospheres (TG = 17.0%, calcd. = 17.0%). The melting was observed at 205 degrees C (DTA) or 203 degrees C (DSC) but this process occurred overlapped with decomposition characteristic of an incongruent melting process. (C) 2009 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 08/04296-3 - Characterization of thermal and mechanical properties of photocured odontologic polymers prepared with different loads
• Grantee: Gilbert Bannach
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 06/06951-3 - Synthesis, characterization and thermoanalytical study of lanthanum (III), lanthanides (III) and yttrium (III) with 2-methoxycinnamilidenepiruvate
• Grantee: Massao Ionashiro
• Support Opportunities: Regular Research Grants