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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low-grade astrocytoma in a child with encephalocraniocutaneous lipomatosis

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Author(s):
Brassesco, Maria Sol [1, 2] ; Valera, Elvis Terci [2] ; Becker, Aline Paixao [3] ; Castro-Gamero, Angel Mauricio [4] ; Machado, Andre de Aboim [5] ; Santos, Antonio Carlos [5] ; Scrideli, Carlos Alberto [2] ; Oliveira, Ricardo Santos [6] ; Machado, Helio Rubens [6] ; Tone, Luiz Gonzaga [2]
Total Authors: 10
Affiliation:
[1] USP, Pediat Lab, Hosp Clin, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Div Pediat Oncol, Dept Pediat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Pathol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Genet, Sao Paulo - Brazil
[5] Univ Sao Paulo, Div Radiol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Div Neurosurg, Dept Surg & Anat, Fac Med Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF NEURO-ONCOLOGY; v. 96, n. 3, p. 437-441, FEB 2010.
Web of Science Citations: 12
Abstract

Encephalocutaneous lipomatosis (ECCL), or Haberland syndrome, is an uncommon congenital disorder with unique cutaneous, ocular and neurological features. In the present article, we describe a 3-year-old boy with ECCL who developed an extensive and recurring intraventricular low-grade glioma with atypical pathological features and elevated mitotic index. Cytogenetic analysis from tumor sample was also performed. This is the first report of a low-grade astrocytoma occurring in a child with ECCL. Whether or not the origin of the tumor is associated to the pathogenesis of the underlying syndrome is a matter for further investigation. (AU)