| Full text | |
| Author(s): |
Murata, Ramiro M.
[1]
;
Branco-de-Almeida, Luciana S.
[1]
;
Franco, Eliane M.
[1]
;
Yatsuda, Regiane
[1]
;
dos Santos, Marcelo H.
[2]
;
de Alencar, Severino M.
[3]
;
Koo, Hyun
[4, 5, 6]
;
Rosalen, Pedro L.
[1, 4]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Physiol Sci, Fac Dent Piracicaba, Campinas, SP - Brazil
[2] Univ Fed Alfenas, UNIFAL MG, Dept Pharm, Alfenas, MG - Brazil
[3] State Univ Sao Paulo, Luiz de Queiroz Coll Agr, Dept Agrifood Ind Food & Nutr, Sao Paulo, SP - Brazil
[4] Nat Prod Res Grp Oral Biol NatPROB, Sao Paulo - Brazil
[5] Univ Rochester, Med Ctr, Ctr Oral Biol, Eastman Dept Dent, Rochester, NY 14627 - USA
[6] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14627 - USA
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | BIOFOULING; v. 26, n. 7, p. 865-872, 2010. |
| Web of Science Citations: | 30 |
| Abstract | |
7-Epiclusianone (7-epi), a novel naturally occurring compound isolated from Rheedia brasiliensis, effectively inhibits the synthesis of exopolymers and biofilm formation by Streptococcus mutans. In the present study, the ability of 7-epi, alone or in combination with fluoride (F), to disrupt biofilm development and pathogenicity of S. mutans in vivo was examined using a rodent model of dental caries. Treatment (twice-daily, 60s exposure) with 7-epi, alone or in combination with 125 ppm F, resulted in biofilms with less biomass and fewer insoluble glucans than did those treated with vehicle-control, and they also displayed significant cariostatic effects in vivo (p < 0.05). The combination 7-epi + 125 ppm F was as effective as 250 ppm F (positive-control) in reducing the development of both smooth-and sulcal-caries. No histopathological alterations were observed in the animals after the experimental period. The data show that 7-epiclusianone is a novel and effective antibiofilm/anticaries agent, which may enhance the cariostatic properties of fluoride. (AU) | |