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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Altered renal sodium handling in spontaneously hypertensive rats (SHR) after hypertonic saline intracerebroventricular injection: Role of renal nerves

Full text
Author(s):
Guadagnini‚ D. ; Gontijo‚ J.A.R.
Total Authors: 2
Document type: Journal article
Source: Life Sciences; v. 79, n. 17, p. 1666-1673, 2006.
Abstract

The mechanism by which blood pressure rises in the SHR strain remains to be elucidated. Also, there is a surprising lack of experimental data on the natriuretic mechanisms induced by intracerebroventricular (ICV) injection of hyperosmotic saline (HoS) in SHR. In normotensive animals ICV injection of HoS causes coordinated responses including natriuresis and inhibition of renal sympathetic nerve activity. In the present study, we hypothesized that presumable blunting of the sympathoinhibitory response to centrally injected HoS may contribute to a lack of suppression of efferent renal nerve outflow in SHR. To test this hypothesis, the present study evaluates the influence of renal denervation after central HoS injection at increasing concentration on urinary sodium handling in SHR compared with age-matched normotensive WKy rats. The study confirmed previous data showing pronounced natriuretic response to centrally HoS stimuli but also demonstrated that the creatinine clearance (C-Cr) and fractional sodium excretion responses diminished as graded NaCl concentrations were increased in WKy rats but not in SHR. In SHR, increased FENa obtained by central administration of 0.90 M NaCl was produced by increases in proximal (FEPNa) and post-proximal fractional urinary sodium rejection without changes in C-Cr, indicating a direct tubular effect. Renal denervation caused significant antinatriuresis by decreased C-Cr and increased FEPNa reabsorption in WKy but not in SHR. This study suggests that natriuresis observed only after higher centrally HoS stimuli with a rightward shift of dose-response curve provides evidence of a down-regulation of target organ responsiveness of periventricular areas of genetic hypertensive rats. (c) 2006 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 00/12216-8 - Cloning and characterization of novel human genes related to spectrin, ankyrin and anion exchangers
Grantee:Sara Teresinha Olalla Saad
Support Opportunities: Research Projects - Thematic Grants