mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor

Author(s):Show less -

Scrideli, Carlos Alberto ^[1] ; Abdala Cortez, Maria Angelica ^[2] ; Yunes, Jose Andres ^[3] ; de Paula Queiroz, Rosane Gomes ^[1] ; Valera, Elvis Terci ^[1] ; da Mata, Juliana Franca ^[1] ; Caminada Teledo, Silvia Regina ^[4] ; Pavoni-Ferreira, Priscila ^[4] ; de Martino Lee, Maria Lucia ^[4] ; Petrilli, Antonio Sergio ^[4] ; Brandalise, Silvia Regina ^{[5, 3]} ; Tone, Luiz Gonzaga ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Dept Pediat, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Genet, BR-14048900 Ribeirao Preto, SP - Brazil

^[3] Ctr Infantil Boldrini, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Inst Pediat Oncol, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Campinas, SP - Brazil

• Document type: Journal article
• Source: Leukemia Research; v. 34, n. 1, p. 32-37, 2010.
• Web of Science Citations: 16

Abstract

This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL. (c) 2009 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 01/13206-9 - Gene expression profiles associated with chemotherapy in acute lymphoid leukemia of childhood
• Grantee: Luiz Gonzaga Tone
• Support Opportunities: Genome Research Grants