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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine

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Author(s):
Sucena, Suelen F. [1] ; Paiva, Raphael E. F. [1] ; Abbehausen, Camilla [1] ; Mattos, Ives B. [2] ; Lancellotti, Marcelo [2] ; Formiga, Andre L. B. [3] ; Corbi, Pedro P. [1]
Total Authors: 7
Affiliation:
[1] Univ Campinas UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, BR-13083970 Sao Paulo - Brazil
[2] Univ Campinas UNICAMP, Inst Biol, Biotechnol Lab, BR-13083970 Sao Paulo - Brazil
[3] Univ Campinas UNICAMP, Inst Chem, Coordinat Chem Lab, BR-13083970 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 89, p. 114-118, APR 2012.
Web of Science Citations: 3
Abstract

A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. H-1, C-13 and N-15 nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of the ligand to Au(I) through the N atom of the ethanamine group. Theoretical (DFT) calculations confirmed the IR assignments and permit proposing an optimized geometry for the complex. The gold(I)-rimantadine complex (Au-RTD) is soluble in methanol, ethanol, dimethylsulfoxide, acetone and acetonitrile. The preliminary kinetic studies based on UV-vis spectroscopic measurements indicate the stability of the compound in solution. Antibacterial activities of the complex were evaluated by an antibiogram assay. The Au-RTD complex showed an effective in vitro antibacterial activity against the Pseudomonas aeruginosa, Escherichia coli (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains. (C) 2011 Elsevier BM. All rights reserved. (AU)