Evaluation of fungi in the stereoselective metabolism of albendazole by high perfo...
Chiral pharmaceuticals in wastewaters: quantification and studies of enantioselect...
| Full text | |
| Author(s): |
Lourenco, Tiago C.
[1]
;
Batista, Jr., Joao M.
[2]
;
Furlan, Maysa
[2]
;
He, Yanan
[3]
;
Nafie, Laurence A.
[4]
;
Santana, Cesar C.
[5]
;
Cass, Quezia B.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Organ Chem, BR-14800900 Araraquara, SP - Brazil
[3] BioTools Inc, Jupiter, FL 33458 - USA
[4] Syracuse Univ, Dept Chem, Syracuse, NY 13244 - USA
[5] State Univ Campinas UNICAMP, Sch Chem Engn, Dept Biotechnol Proc, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Journal of Chromatography A; v. 1230, p. 61-65, MAR 23 2012. |
| Web of Science Citations: | 19 |
| Abstract | |
The enantiomeric separation of albendazole sulfoxide was carried out by simulated moving bed chromatography with variable zones (VARICOL). An overall recovery of 97% was achieved and enantiomeric ratios of 99.5% for raffinate and 99.0% for extract were attained. A total of 880 mg of (+)-albendazol sulfoxide and 930 mg of its antipode were collected after 55 cycles or 11 h of process, resulting in a mass rate of 2 g/day. Furthermore the absolute configuration of the enantiopure compounds was determined for the first time by vibrational circular dichroism (VCD) with the aid of theoretical calculations as (-)-(S) and (+)-(R)-albendazole sulfoxide. (C) 2012 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 09/17138-0 - Methods for quantification of small molecules in biological fluids: the use of restricted access media columns for direct injection of samples |
| Grantee: | Quezia Bezerra Cass |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/18515-1 - Simulated moving bed chromatography (Varicol): a case study for the purification of enantiomers |
| Grantee: | Tiago de Campos Lourenço |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 07/02872-4 - Application of simulated moving beds with variable zone lenght (Varicol) for the obtention of enantiomers of biologically active compounds |
| Grantee: | Cesar Costapinto Santana |
| Support Opportunities: | Research Projects - Thematic Grants |