| Full text | |
| Author(s): |
Felippotti, Tatiana Tocchini
[1, 2, 3]
;
de Freitas, Renato Leonardo
[1, 2]
;
Coimbra, Norberto Cysne
[1, 2, 3]
Total Authors: 3
|
| Affiliation: | [1] Inst Neurosci & Behav INeC, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo FMRP USP, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Div Neurol, Postgrad Program, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Neuropeptides; v. 46, n. 1, p. 39-47, FEB 2012. |
| Web of Science Citations: | 14 |
| Abstract | |
Background: The aim of the present work was to investigate the involvement of the mu(1)-endogenous opioid peptide receptor-mediated system in post-ictal antinociception. Methods: Antinociceptive responses were determined by the tail-flick test after pre-treatment with the selective mu(1)-opioid receptor antagonist naloxonazine, peripherally or centrally administered at different doses. Results: Peripheral subchronic (24 h) pre-treatment with naloxonazine antagonised the antinociception elicited by tonic-clonic seizures. Acute (10 min) pre-treatment, however, did not have the same effect. In addition, microinjections of naloxonazine into the central, dorsal cortical and external cortical nuclei of the inferior colliculus antagonised tonic-clonic seizure-induced antinociception. Neither acute (10-min) peripheral pre-treatment with naloxonazine nor subchronic intramesencephalic blockade of mu(1)-opioid receptors resulted in consistent statistically significant differences in the severity of tonic-clonic seizures shown by Racine's index (1972), although the intracollicular specific antagonism of mu(1)-opioid receptor decreased the duration of seizures. Conclusion: mu(1)-Opioid receptors and the inferior colliculus have been implicated in several endogenous opioid peptide-mediated responses such as antinociception and convulsion. The present findings suggest the involvement of mu(1)-opiate receptors of central and pericentral nuclei of the inferior colliculus in the modulation of tonic-clonic seizures and in the organisation of post-ictal antinociception. (C) 2011 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 03/05256-1 - Caracterizacao de receptores serotoninergicos na analgesia pos-ictal: envolvimento do nucleo dorsal da rafe. |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 01/03752-6 - Estudo do envolvimento de receptores m-opioides, colinergicos muscarinico e nicotinico e serotonergicos 5-ht2/1c na analgesia pos-ictal. |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 02/01497-1 - Estudo do envolvimento do núcleo magno da rafe, do núcleo gigantocelular e núcleo pré-tectal anterior, e de receptores opiódes, kappa e delta serotoninérgicos 5HT2/1C, e noradrenérgicos alfa, beta, na analgesia pós-cital: um estudo neuroanatômico e neuropsicofisiológico em um modelo experimental de epilepsia |
| Grantee: | Daoud Hibrahim Elias Filho |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |
| FAPESP's process: | 09/00668-6 - Study of the involvement of cholinergic pathways form tegmentar pedunculopontine nucleus to monoaminergic nuclei of the pain endogenous inhibitory system in the post-ictal antinociception |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/17258-5 - Study of the involvement of nitrergic system and of glutamatergic and cannabinoid-mediated neurotransmission from the medial prefrontal cortex in the analgesia induced by elaborated escape reactions evoked by GABAergic blockade in the medial hypothalamus |
| Grantee: | Renato Leonardo de Freitas |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 03/09129-4 - Estudo do envolvimento dos receptores opioides mu 1 e dos corpos quadrigemeos na analgesia pos-ictal. |
| Grantee: | Tatiana Tocchini Felippotti |
| Support Opportunities: | Scholarships in Brazil - Master |