| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Campinas UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Journal of Pharmaceutical and Biomedical Analysis; v. 58, p. 42-48, JAN 25 2012. |
| Web of Science Citations: | 7 |
| Abstract | |
Ointment dosage forms are semi-solid preparations intended for local or transdermal delivery of active substances usually for application to the skin and it is important that they present a homogeneous appearance. In this work, a study of the homogeneity of a tacrolimus ointment dosage form was performed using infrared imaging spectroscopy coupled with principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS) to interpret the imaging data. Optical visible microscopy images indicated possible phase separation in the ointment and, based on the results presented by distribution concentration maps from infrared imaging, it was possible to conclude that, in fact, there was phase separation incorporated in the ointment. Thus, infrared imaging spectroscopy associated to PCA and MCR-ALS is demonstrated to be a powerful tool for the development process of ointment dosage forms. (C) 2011 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 06/07309-3 - Novel analytical strategies for studies involving biomolecules |
| Grantee: | Elias Ayres Guidetti Zagatto |
| Support Opportunities: | Research Projects - Thematic Grants |