| Full text | |
| Author(s): |
Yamamoto, Aparecida Y.
[1]
;
Mussi-Pinhata, Marisa Marcia
[1]
;
Isaac, Myriam de Lima
[2]
;
Amaral, Fabiana R.
[1]
;
Carvalheiro, Cristina G.
[1]
;
Aragon, Davi C.
[1]
;
da Silva Manfredi, Alessandra K.
[1]
;
Boppana, Suresh B.
[3, 4]
;
Britt, William J.
[3, 4, 5]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Ophtalmol Otorrinolaringol & Head & Neck Sur, Fac Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil
[3] Univ Alabama, Sch Med, Dept Pediat, Birmingham, AL - USA
[4] Univ Alabama, Sch Med, Dept Microbiol, Birmingham, AL 35294 - USA
[5] Univ Alabama, Sch Med, Dept Neurobiol, Birmingham, AL - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | PEDIATRIC INFECTIOUS DISEASE JOURNAL; v. 30, n. 12, p. 1043-1046, DEC 2011. |
| Web of Science Citations: | 67 |
| Abstract | |
Background: The burden of congenital cytomegalovirus (CMV)-associated sensorineural hearing loss (SNHL) in populations with CMV seroprevalence approaching 100% is unknown. The purpose of this study was to assess the rate, associated factors, and predictors of SNHL in CMV-infected infants identified by newborn screening in a highly seropositive maternal population. Methods: Newborns with positive saliva CMV-DNA that was confirmed by virus isolation in the first 2 weeks of life were enrolled in a prospective follow-up study to monitor hearing outcome. Results: Of 12,195 infants screened, 121 (1%) were infected with CMV and 12 (10%) had symptomatic infection at birth. Hearing function could be assessed in 102/121 children who underwent at least one auditory brainstem evoked response testing at a median age of 12 months. SNHL was observed in 10/102 (9.8%; 95% confidence interval: 5.1-16.7) children. Median age at the latest hearing evaluation was 47 months (12-84 months). Profound loss (>90 dB) was found in 4/5 children with bilateral SNHL while all 5 children with unilateral loss had moderate to severe deficit. The presence of symptomatic infection at birth (odds ratio, 38.1; 95% confidence interval: 1.6-916.7) was independently associated with SNHL after adjusting for intrauterine growth restriction, gestational age, gravidity, and maternal age. Among 10 infants with SNHL, 6 (60%) were born to mothers with nonprimary CMV infection. Conclusions: Even in populations with near universal immunity to CMV, congenital CMV infection is a significant cause of SNHL demonstrating the importance of CMV as a major cause of SNHL in children worldwide. As in other populations, SNHL is more frequently observed in symptomatic CMV infection. (AU) | |