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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of erythrosine- and LED-mediated photodynamic therapy on buccal candidiasis infection of immunosuppressed mice and Candida albicans adherence to buccal epithelial cells

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Author(s):
Borges Pereira Costa, Anna Carolina [1] ; Campos Rasteiro, Vanessa Maria [1] ; Halter da Silva Hashimoto, Emily Setsuko [1] ; Araujo, Cassia Fernandes [1] ; Pereira, Cristiane Aparecida [1] ; Junqueira, Juliana Campos [1] ; Cardoso Jorge, Antonio Olavo [1]
Total Authors: 7
Affiliation:
[1] UNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 114, n. 1, p. 67-74, JUL 2012.
Web of Science Citations: 31
Abstract

Objective. This study evaluated the effects of photodynamic therapy (PDT) on buccal candidiasis in mice and on the adherence of yeast to buccal epithelial cells (BECs) in vitro. Study Design. A total of 56 immunosuppressed mice with buccal candidiasis were subjected to PDT, consisting of treatment with erythrosine (400 mu mol/L) followed by exposure to a green LED (14.34 J cm(-2)). After treatment, the yeasts recovered from the mice were quantified (CFU/mL) and analyzed for the effects of PDT on their adherence to BECs. The data were analyzed using ANOVA, the Tukey test, Kruskal-Wallis test and Student t test. Results. PDT significantly reduced the amount of yeast present in the lesions by 0.73 log(10) (P = .018) and reduced C. albicans adherence to BECs by 35% without damaging adjacent tissues (P = .045). Conclusions. Photodynamic therapy exhibited antifungal effects against C. albicans biofilms formed in vivo and reduced the capacity of C. albicans to adhere to BECs in vitro. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:67-74) (AU)

FAPESP's process: 10/01988-1 - Evaluation of photodynamic therapy on immunosuppressed mice with oral candidosis induced by Candida albicans
Grantee:Emily Setsuko Halter Hashimoto Miranda
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/18753-7 - Evaluation of photodynamic therapy on Candida albicans in vitro and in vivo
Grantee:Antonio Olavo Cardoso Jorge
Support Opportunities: Regular Research Grants
FAPESP's process: 09/52048-1 - Effects of photodynamic therapy and essential oils of the Cymbopogon citratus (DC.) Stapf, Casearia sylvestris SW and Curcuma zedoaria Roscoe, in vitro, in biofilms of Candida albicans, Staphylococcus aureus and Streptococcus mutans
Grantee:Antonio Olavo Cardoso Jorge
Support Opportunities: Regular Research Grants
FAPESP's process: 09/12005-1 - Evaluation of photodynamic therapy in Candida albicans in vitro and in vivo
Grantee:Anna Carolina Borges Pereira da Costa
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/00879-4 - OPPORTUNISTIC MICROORGANISMS IN INJURIES denture stomatitis AND INFLUENCE OF PHOTODYNAMIC THERAPY IN VIRULENCE FACTORS OF Candida spp.
Grantee:Cristiane Aparecida Pereira Correia
Support Opportunities: Scholarships in Brazil - Doctorate